Iglesia Santo Domingo, founded in 1534, is the oldest church in Cartagena and one of the first in the hemisphere. The original stone structure, finished in 1551, was so badly damaged by Sir Francis Drake in 1586 that a new church needed to be built; the current incarnation was finally completed some time during the 1700s.
The cool, spacious interior, with its imposing central nave lined with massive stone columns and inspiring marble altar are unusual, and certainly worth a look. Most travelers will spend more time on Plaza Santo Domingo, right out front, the spot to enjoy a little rest and relaxation of a premium-priced beverage. Surrounded by some of the city’s finest architecture, and filled with umbrella-shaded café tables, the plaza is also a magnet for souvenir vendors. Be sure to bargain.